Top 5 Weight Loss Medications
1
Ozempic / Wegovy
Semaglutide
Manufactured by Novo Nordisk
The most talked-about weight loss drug in modern medicine. Semaglutide is a GLP-1 receptor agonist
originally approved for type 2 diabetes (Ozempic) and later approved specifically for chronic weight
management at higher doses (Wegovy). Clinical trials showed up to 15–17% average body weight reduction.
Administered as a once-weekly injection.
2
Mounjaro / Zepbound
Tirzepatide
Manufactured by Eli Lilly and Company
Tirzepatide is a first-in-class dual GIP and GLP-1 receptor agonist. Approved as Mounjaro for diabetes and
as Zepbound for weight management, it has demonstrated some of the highest weight loss results in clinical
trials — up to 22.5% reduction in body weight. Once-weekly subcutaneous injection.
3
Qsymia
Phentermine / Topiramate ER
Manufactured by Vivus Pharmaceuticals
An FDA-approved oral combination medication pairing phentermine (appetite suppressant) with extended-release
topiramate (anticonvulsant with weight-loss properties). One of the most effective oral options available,
with average weight reductions of 9–10% over 12 months. Taken once daily in the morning.
4
Contrave
Naltrexone / Bupropion
Manufactured by Currax Pharmaceuticals
An FDA-approved oral combination of naltrexone (opioid antagonist) and bupropion (antidepressant / smoking
cessation aid). Works by targeting reward pathways in the brain to reduce food cravings and hunger.
Clinical studies showed approximately 5–9% average weight loss. Taken as an oral tablet twice daily.
5
Xenical / Alli
Orlistat
Manufactured by Roche / GSK (OTC)
One of the longest-established weight loss medications, orlistat works by blocking about one-third of
dietary fat from being absorbed in the gut. Available by prescription as Xenical (120mg) and over-the-counter
as Alli (60mg). Typically produces 5–7% average body weight reduction. Taken orally with each fat-containing meal.
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